CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Unrelated cord blood transplantation for childhood acute myeloid leukemia: a Eurocord Group analysis
نویسندگان
چکیده
Gerard Michel, Vanderson Rocha, Sylvie Chevret, William Arcese, Kah-Wah Chan, Alexandra Filipovich, Tsuneo A. Takahashi, Marcus Vowels, Juan Ortega, Pierre Bordigoni, Peter J. Shaw, Isaac Yaniv, Alexandra Machado, Pedro Pimentel, Franca Fagioli, Amparo Verdeguer, Jean Pierre Jouet, Blanca Diez, Euripedes Ferreira, Ricardo Pasquini, Joseph Rosenthal, Eric Sievers, Chiara Messina, Anna Paola Iori, Federico Garnier, Irina Ionescu, Franco Locatelli, and Eliane Gluckman, for the Eurocord Group
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease
Franco Locatelli, Vanderson Rocha, William Reed, Françoise Bernaudin, Mehmet Ertem, Stelios Grafakos, Benedicte Brichard, Xiaxin Li, Arnon Nagler, Giovanna Giorgiani, Paul R. Haut, Joel A. Brochstein, Diane J. Nugent, Julie Blatt, Paul Woodard, Joanne Kurtzberg, Charles M. Rubin, Roberto Miniero, Patrick Lutz, Thirumalairaj Raja, Irene Roberts, Andrew M. Will, Isaac Yaniv, Christiane Vermylen, ...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen–matched unrelated donor bone marrow: results of a matched-pair analysis
Umbilical cord blood (UCB) is being increasingly used for hematopoietic stem cell transplantation and has been associated with a reduced incidence of severe graft-versus-host disease (GVHD). To further investigate the relative merits of unrelated donor UCB versus bone marrow (BM), a matched-pair analysis comparing the outcomes of recipients of 0 to 3 human leukocyte antigen (HLA)–mismatched UCB...
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Despite improvements in the treatment of acute myeloid leukemia (AML), approximately 50% of children die of the disease. Clinical trials in adult patients with AML indicate that idarubicin may have superior efficacy when compared to daunorubicin in the remission-induction phases of chemotherapy. We conducted consecutive clinical trials in children with newly diagnosed AML in which daunorubicin ...
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To describe the clinical and biologic features of pediatric acute megakaryoblastic leukemia (AMKL) and to identify prognostic factors, experience at St Jude Children’s Research Hospital was reviewed. Of 281 patients with acute myeloid leukemia treated over a 14-year period, 41 (14.6%) had a diagnosis of AMKL. Six patients had Down syndrome and AMKL, 6 had secondary AMKL, and 29 had de novo AMKL...
متن کاملCLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Unrelated donor stem cell transplantation compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission: a matched-pair analysis
Allogeneic stem cell transplantation (SCT) is frequently considered as treatment for relapsed childhood acute lymphoblastic leukemia (ALL). For patients without a matched sibling donor, SCT from unrelated donors (UD-SCT) has been increasingly performed during the past years. However, UD-SCT–related mortality and morbidity is still considerable, and the question remains as to which patients are ...
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